Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery.
نویسندگان
چکیده
The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.
منابع مشابه
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background
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ورودعنوان ژورنال:
- Journal of virology
دوره 72 10 شماره
صفحات -
تاریخ انتشار 1998